U.S. stocks lower at close of trade; Dow Jones Industrial Average down 1.07%

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At the close in NYSE, the Dow Jones Industrial Average fell 1.07%, while the S&P 500 index lost 1.94%, and the NASDAQ Composite index declined 3.34%.

The best performers of the session on the Dow Jones Industrial Average were Merck & Company Inc (NYSE:MRK), which rose 2.43% or 1.87 points to trade at 78.88 at the close. Meanwhile, Intel Corporation (NASDAQ:INTC) added 1.37% or 0.73 points to end at 53.87 and Walmart Inc (NYSE:WMT) was up 1.35% or 1.92 points to 143.92 in late trade.

The worst performers of the session were Salesforce.com Inc (NYSE:CRM), which fell 8.28% or 20.56 points to trade at 227.67 at the close. Microsoft Corporation (NASDAQ:MSFT) declined 3.84% or 12.63 points to end at 316.38 and Apple Inc (NASDAQ:AAPL) was down 2.66% or 4.78 points to 174.92.

The top performers on the S&P 500 were Nucor Corp (NYSE:NUE) which rose 4.83% to 122.72, Merck & Company Inc (NYSE:MRK) which was up 2.43% to settle at 78.88 and AT&T Inc (NYSE:T) which gained 2.22% to close at 26.21.

The worst performers were Enphase Energy Inc (NASDAQ:ENPH) which was down 11.82% to 157.20 in late trade, Salesforce.com Inc (NYSE:CRM) which lost 8.28% to settle at 227.67 and Paycom Soft (NYSE:PAYC) which was down 7.93% to 360.78 at the close.

The top performers on the NASDAQ Composite were Lixte Biotechnology Holdings Inc (NASDAQ:LIXT) which rose 63.70% to 2.210, Mainz Biomed BV (NASDAQ:MYNZ) which was up 46.39% to settle at 15.21 and BTCS Inc (NASDAQ:BTCS) which gained 43.89% to close at 4.3600.

The worst performers were Annexon Inc (NASDAQ:ANNX) which was down 34.06% to 7.26 in late trade, Applied Therapeutics Inc (NASDAQ:APLT) which lost 23.54% to settle at 4.45 and Monte Rosa Therapeutics Inc (NASDAQ:GLUE) which was down 22.62% to 15.63 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 2624 to 640 and 124 ended unchanged; on the Nasdaq Stock Exchange, 3033 fell and 823 advanced, while 171 ended unchanged.

Shares in Annexon Inc (NASDAQ:ANNX) fell to all time lows; down 34.06% or 3.75 to 7.26. Shares in Mainz Biomed BV (NASDAQ:MYNZ) rose to all time highs; rising 46.39% or 4.82 to 15.21. Shares in Applied Therapeutics Inc (NASDAQ:APLT) fell to all time lows; losing 23.54% or 1.37 to 4.45. Shares in Monte Rosa Therapeutics Inc (NASDAQ:GLUE) fell to all time lows; falling 22.62% or 4.57 to 15.63.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was up 16.68% to 19.73.

Gold Futures for February delivery was down 0.23% or 4.10 to $1810.50 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in February rose 0.30% or 0.23 to hit $77.22 a barrel, while the March Brent oil contract rose 0.11% or 0.09 to trade at $80.22 a barrel.

EUR/USD was unchanged 0.00% to 1.1313, while USD/JPY rose 0.00% to 116.11.

The US Dollar Index Futures was down 0.10% at 96.175.