U.S. stocks mixed at close of trade; Dow Jones Industrial Average down 0.45%

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At the close in NYSE, the Dow Jones Industrial Average fell 0.45%, while the S&P 500 index declined 0.14%, and the NASDAQ Composite index gained 0.05%.

The best performers of the session on the Dow Jones Industrial Average were Intel Corporation (NASDAQ:INTC), which rose 3.31% or 1.77 points to trade at 55.21 at the close. Meanwhile, Merck & Company Inc (NYSE:MRK) added 2.58% or 2.07 points to end at 82.37 and UnitedHealth Group Incorporated (NYSE:UNH) was up 1.40% or 6.40 points to 465.00 in late trade.

The worst performers of the session were Nike Inc (NYSE:NKE), which fell 4.16% or 6.53 points to trade at 150.44 at the close. Boeing Co (NYSE:BA) declined 2.87% or 6.19 points to end at 209.31 and Visa Inc Class A (NYSE:V) was down 2.30% or 4.99 points to 211.97.

The top performers on the S&P 500 were Moderna Inc (NASDAQ:MRNA) which rose 9.28% to 233.70, Humana Inc (NYSE:HUM) which was up 6.06% to settle at 385.18 and Hologic Inc (NASDAQ:HOLX) which gained 4.47% to close at 73.45.

The worst performers were Take-Two Interactive Software Inc (NASDAQ:TTWO) which was down 13.13% to 142.99 in late trade, Cardinal Health Inc (NYSE:CAH) which lost 5.92% to settle at 51.03 and Estee Lauder Companies Inc (NYSE:EL) which was down 5.36% to 335.89 at the close.

The top performers on the NASDAQ Composite were Bone Biologics Corp (NASDAQ:BBLG) which rose 57.14% to 5.39, Zynga Inc (NASDAQ:ZNGA) which was up 40.67% to settle at 8.44 and Molecular Partners AG ADR (NASDAQ:MOLN) which gained 30.22% to close at 21.50.

The worst performers were TDH Holdings Inc (NASDAQ:PETZ) which was down 81.86% to 0.740 in late trade, Kidpik Corp (NASDAQ:PIK) which lost 27.47% to settle at 4.75 and Rapid Micro Biosystems Inc (NASDAQ:RPID) which was down 21.23% to 7.20 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 2052 to 1186 and 158 ended unchanged; on the Nasdaq Stock Exchange, 2493 fell and 1368 advanced, while 206 ended unchanged.

Shares in Take-Two Interactive Software Inc (NASDAQ:TTWO) fell to 52-week lows; down 13.13% or 21.61 to 142.99. Shares in TDH Holdings Inc (NASDAQ:PETZ) fell to 52-week lows; down 81.86% or 3.340 to 0.740. Shares in Kidpik Corp (NASDAQ:PIK) fell to all time lows; losing 27.47% or 1.80 to 4.75. Shares in Molecular Partners AG ADR (NASDAQ:MOLN) rose to all time highs; rising 30.22% or 4.99 to 21.50. Shares in Rapid Micro Biosystems Inc (NASDAQ:RPID) fell to all time lows; losing 21.23% or 1.94 to 7.20.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was up 3.41% to 19.40.

Gold Futures for February delivery was up 0.21% or 3.85 to $1801.25 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in February fell 0.62% or 0.49 to hit $78.41 a barrel, while the March Brent oil contract unchanged 0.00% or 0.00 to trade at $81.02 a barrel.

EUR/USD was up 0.03% to 1.1327, while USD/JPY unchanged 0.00% to 115.20.

The US Dollar Index Futures was up 0.23% at 95.938.