U.S. stocks mixed at close of trade; Dow Jones Industrial Average down 0.28%

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At the close in NYSE, the Dow Jones Industrial Average fell 0.28% to hit a new 3-months low, while the S&P 500 index fell 0.15%, and the NASDAQ Composite index added 0.45%.

The best performers of the session on the Dow Jones Industrial Average were Amgen Inc (NASDAQ:AMGN), which rose 2.33% or 5.31 points to trade at 233.18 at the close. Meanwhile, Microsoft Corporation (NASDAQ:MSFT) added 2.14% or 5.33 points to end at 253.92 and Salesforce Inc (NYSE:CRM) was up 1.35% or 2.34 points to 175.52 in late trade.

The worst performers of the session were American Express Company (NYSE:AXP), which fell 4.89% or 8.10 points to trade at 157.60 at the close. Goldman Sachs Group Inc (NYSE:GS) declined 3.48% or 11.41 points to end at 316.26 and Dow Inc (NYSE:DOW) was down 2.77% or 1.49 points to 52.39.

The top performers on the S&P 500 were Illumina Inc (NASDAQ:ILMN) which rose 16.97% to 226.94, Newmont Goldcorp Corp (NYSE:NEM) which was up 6.95% to settle at 45.09 and Moderna Inc (NASDAQ:MRNA) which gained 6.95% to close at 147.90.

The worst performers were First Republic Bank (NYSE:FRC) which was down 61.83% to 31.21 in late trade, Comerica Inc (NYSE:CMA) which lost 27.68% to settle at 42.53 and KeyCorp (NYSE:KEY) which was down 27.08% to 11.42 at the close.

The top performers on the NASDAQ Composite were Provention Bio Inc (NASDAQ:PRVB) which rose 259.70% to 24.10, Cipher Mining Inc (NASDAQ:CIFR) which was up 37.88% to settle at 1.82 and EUDA Health Holdings Ltd (NASDAQ:EUDA) which gained 36.63% to close at 2.76.

The worst performers were Genelux Corp (NASDAQ:GNLX) which was down 36.16% to 14.25 in late trade, icad inc (NASDAQ:ICAD) which lost 35.56% to settle at 1.54 and First Foundation Inc (NASDAQ:FFWM) which was down 33.07% to 7.75 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 2180 to 877 and 65 ended unchanged; on the Nasdaq Stock Exchange, 2304 fell and 1350 advanced, while 123 ended unchanged.

Shares in First Republic Bank (NYSE:FRC) fell to 5-year lows; falling 61.83% or 50.55 to 31.21. Shares in Comerica Inc (NYSE:CMA) fell to 52-week lows; losing 27.68% or 16.28 to 42.53. Shares in KeyCorp (NYSE:KEY) fell to 52-week lows; down 27.08% or 4.24 to 11.42. Shares in Provention Bio Inc (NASDAQ:PRVB) rose to all time highs; up 259.70% or 17.40 to 24.10. Shares in icad inc (NASDAQ:ICAD) fell to all time lows; down 35.56% or 0.85 to 1.54. Shares in First Foundation Inc (NASDAQ:FFWM) fell to all time lows; losing 33.07% or 3.83 to 7.75.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was up 6.94% to 26.52 a new 3-months high.

Gold Futures for April delivery was up 2.77% or 51.70 to $1,918.90 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in April fell 2.60% or 1.99 to hit $74.69 a barrel, while the May Brent oil contract rose 0.07% or 0.06 to trade at $80.75 a barrel.

EUR/USD was unchanged 0.00% to 1.07, while USD/JPY rose 0.03% to 133.23.

The US Dollar Index Futures was down 0.89% at 103.22.