U.S. stocks lower at close of trade; Dow Jones Industrial Average down 0.30%

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At the close in NYSE, the Dow Jones Industrial Average lost 0.30%, while the S&P 500 index declined 0.75%, and the NASDAQ Composite index lost 1.14%.

The best performers of the session on the Dow Jones Industrial Average were The Travelers Companies Inc (NYSE:TRV), which rose 2.32% or 3.55 points to trade at 156.73 at the close. Meanwhile, Merck & Company Inc (NYSE:MRK) added 1.36% or 0.99 points to end at 73.72 and Amgen Inc (NASDAQ:AMGN) was up 1.11% or 2.35 points to 213.74 in late trade.

The worst performers of the session were Salesforce.com Inc (NYSE:CRM), which fell 3.83% or 10.17 points to trade at 255.59 at the close. Microsoft Corporation (NASDAQ:MSFT) declined 3.26% or 11.06 points to end at 328.34 and Cisco Systems Inc (NASDAQ:CSCO) was down 1.43% or 0.84 points to 57.77.

The top performers on the S&P 500 were Centene Corp (NYSE:CNC) which rose 4.71% to 81.83, Macy’s Inc (NYSE:M) which was up 3.95% to settle at 25.78 and Nordstrom Inc (NYSE:JWN) which gained 3.27% to close at 20.24.

The worst performers were Adobe Systems Incorporated (NASDAQ:ADBE) which was down 6.60% to 614.86 in late trade, MSCI Inc (NYSE:MSCI) which lost 4.94% to settle at 591.07 and Fortinet Inc (NASDAQ:FTNT) which was down 4.76% to 315.80 at the close.

The top performers on the NASDAQ Composite were Galera Therapeutics Inc (NASDAQ:GRTX) which rose 95.65% to 2.700, Mind Technology Inc (NASDAQ:MIND) which was up 29.93% to settle at 1.7800 and Alzamend Neuro Inc (NASDAQ:ALZN) which gained 28.33% to close at 3.08.

The worst performers were Adagio Therapeutics Inc (NASDAQ:ADGI) which was down 78.81% to 7.26 in late trade, Cabaletta Bio Inc (NASDAQ:CABA) which lost 73.14% to settle at 3.360 and Generation Bio Co (NASDAQ:GBIO) which was down 56.91% to 5.99 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 2298 to 973 and 138 ended unchanged; on the Nasdaq Stock Exchange, 2652 fell and 1155 advanced, while 201 ended unchanged.

Shares in Centene Corp (NYSE:CNC) rose to all time highs; rising 4.71% or 3.68 to 81.83. Shares in Adagio Therapeutics Inc (NASDAQ:ADGI) fell to all time lows; losing 78.81% or 27.00 to 7.26. Shares in Cabaletta Bio Inc (NASDAQ:CABA) fell to all time lows; down 73.14% or 9.150 to 3.360. Shares in Generation Bio Co (NASDAQ:GBIO) fell to all time lows; down 56.91% or 7.91 to 5.99.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was up 7.78% to 21.89.

Gold Futures for February delivery was down 0.95% or 16.95 to $1771.35 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in January fell 1.39% or 0.99 to hit $70.30 a barrel, while the February Brent oil contract fell 0.03% or 0.02 to trade at $73.22 a barrel.

EUR/USD was up 0.02% to 1.1259, while USD/JPY rose 0.02% to 113.74.

The US Dollar Index Futures was up 0.26% at 96.523.