Morgan Stanley sees Eli Lilly's Donanemab achieving higher rate of ARIA

This post was originally published on this site

Eli Lilly (NYSE:LLY) is a catalyst-driven idea at Morgan Stanley, analysts said in a note Friday, based on Topline Ph3 data for the company’s Alzheimer’s drug Donanemab, which is expected in the second quarter.

“Eli Lilly plans to report topline 18-month donanemab Ph3 TRAILBLAZER-2 results in 2Q23. This will be the third Ph3 Alzheimer’s readout following positive Biogen/Eisai lecanemab CLARITY AD results and negative Roche gantenerumab GRADUATE I/II results,” explained analysts.

The analysts outlined six potential scenarios that could play out, including:

Morgan Stanley’s base case is scenario four which would see Donanemab have a comparable efficacy and higher rate of ARIA.

Overall, analysts said the firm is focused on cognitive improvement and rates of symptomatic ARIA as key criteria to compare Dmab to lecanemab.