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Revenue from COVID-19 antibody therapies rose to $1.47 billion in the quarter, from $810.1 million a year earlier.
Sales of its blockbuster diabetes drug Trulicity rose 20% to $1.74 billion.
The company, however, lowered its full-year profit forecast.
It now expects adjusted full-year earnings of between $8.15 and $8.30 per share, compared with its prior forecast of $8.50 to $8.65 per share.
Net income rose to $1.90 billion, or $2.10 per share, in the first quarter ended March 31, from $1.36 billion, or $1.49 per share, a year ago.
