U.S. stocks lower at close of trade; Dow Jones Industrial Average down 0.56%

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At the close in NYSE, the Dow Jones Industrial Average declined 0.56% to hit a new 1-month low, while the S&P 500 index lost 1.13%, and the NASDAQ Composite index fell 1.43%.

The best performers of the session on the Dow Jones Industrial Average were UnitedHealth Group Incorporated (NYSE:UNH), which rose 2.62% or 13.37 points to trade at 523.14 at the close. Meanwhile, JPMorgan Chase & Co (NYSE:JPM) added 1.51% or 1.75 points to end at 117.87 and Goldman Sachs Group Inc (NYSE:GS) was up 1.33% or 4.36 points to 331.62 in late trade.

The worst performers of the session were Salesforce Inc (NYSE:CRM), which fell 3.46% or 5.55 points to trade at 154.73 at the close. Microsoft Corporation (NASDAQ:MSFT) declined 2.71% or 6.84 points to end at 245.38 and Visa Inc Class A (NYSE:V) was down 2.06% or 4.10 points to 195.31.

The top performers on the S&P 500 were Humana Inc (NYSE:HUM) which rose 8.34% to 497.10, Wynn Resorts Limited (NASDAQ:WYNN) which was up 7.48% to settle at 65.23 and Paramount Global Class B (NASDAQ:PARA) which gained 5.16% to close at 23.05.

The worst performers were Adobe Systems Incorporated (NASDAQ:ADBE) which was down 16.79% to 309.13 in late trade, Albemarle Corp (NYSE:ALB) which lost 6.49% to settle at 286.74 and West Pharmaceutical Services Inc (NYSE:WST) which was down 5.91% to 273.63 at the close.

The top performers on the NASDAQ Composite were Heartbeam Inc (NASDAQ:BEAT) which rose 85.60% to 2.32, Neurobo Pharmaceuticals Inc (NASDAQ:NRBO) which was up 47.21% to settle at 24.82 and Nabriva Therapeutics AG (NASDAQ:NBRV) which gained 40.65% to close at 0.27.

The worst performers were Shuttle Pharmaceuticals Inc (NASDAQ:SHPH) which was down 55.65% to 16.63 in late trade, Eloxx Pharmaceuticals Inc (NASDAQ:ELOX) which lost 40.97% to settle at 0.22 and Color Star Technology Co Ltd (NASDAQ:CSCW) which was down 39.54% to 0.07 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 2189 to 911 and 116 ended unchanged; on the Nasdaq Stock Exchange, 1998 fell and 1769 advanced, while 226 ended unchanged.

Shares in Adobe Systems Incorporated (NASDAQ:ADBE) fell to 52-week lows; losing 16.79% or 62.39 to 309.13. Shares in West Pharmaceutical Services Inc (NYSE:WST) fell to 52-week lows; falling 5.91% or 17.19 to 273.63. Shares in Heartbeam Inc (NASDAQ:BEAT) rose to all time highs; gaining 85.60% or 1.07 to 2.32. Shares in Eloxx Pharmaceuticals Inc (NASDAQ:ELOX) fell to all time lows; falling 40.97% or 0.16 to 0.22. Shares in Color Star Technology Co Ltd (NASDAQ:CSCW) fell to all time lows; falling 39.54% or 0.05 to 0.07.

The CBOE Volatility Index, which measures the implied volatility of S&P 500 options, was up 0.42% to 26.27.

Gold Futures for December delivery was down 2.08% or 35.55 to $1,673.55 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in October fell 3.84% or 3.40 to hit $85.08 a barrel, while the November Brent oil contract fell 3.55% or 3.34 to trade at $90.76 a barrel.

EUR/USD was unchanged 0.19% to 1.00, while USD/JPY rose 0.23% to 143.48.

The US Dollar Index Futures was up 0.06% at 109.44.